1918 Spanish Influenza Wikipedia

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Spanish influenza n. that caused several waves of pandemic in 1918–1919, resulting in over 20 million deaths Wikipedia: 1918 flu pandemic The 1918 flu pandemic (commonly referred to as the Spanish flu) was an pandemic that spread to nearly every part of the world.This Web site accompanies a film broadcast by the US Public Broadcasting Service about the outbreak in the United States in 1918, the so-called "Spanish flu". The site contains a full transcript of Entry in Wikipedia (free online encyclopedia) gives clear overview of the pandemic The Spanish Influenza 1918 He was referring to the influenza pandemic of 1918-1919 that infected 20% of the world's population and killed between 60 and 100 million people. This is roughly 3 times as many as were killed and wounded in World War One, Tending Nurse Claimed Spanish Influenza Outbreak of 1918 Caused by Vaccinations (Dec. 9, 2006);William Robert himself moved to Lancashire in the early 1890s, joined the police in January 1894 and reached the rank of Inspector 1917. Sadly, he died shortly after in the great 1918 Flue Epidemic. He was only 46. Link to Wikipedia article on the Great 1918 Spanish Influenza Pandemic.Crosby, Alfred W. (1990). America's Forgotten Pandemic: The of 1918, Cambridge: Oxford JS, Sefton A, Jackson R, Innes W, Daniels RS, Johnson NP (2002).

"World War I may have allowed the emergence of "Spanish" influenza". The Lancet infectious diseases 2 (2): 111-4. Dari Wikipedia Bahasa Melayu, ensiklopedia bebas.If such a mutation happens there is the fear that a global pandemic could spread with deaths that could rival the 1918 Spanish influenza epidemic.Christopher F. Basler, Patricia V. Aguilar, Hui Zeng, Alicia Solórzano, David E. Swayne, Nancy J. Cox, Jacqueline M. Katz, Jeffery K. Taubenberger, Peter Palese and Adolfo García-Sastre (2005). "Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus".

Wikipedia encyclopedia or Spanish epidemic influenza epidemic of 1918–19; Influenza Genome Sequencing Project; Influenza in birds; Influenza in birds; in birds; Influenza Like Illness; Influenza of 1918; Influenza pandemic; Influenza pandemic of 1918;For the first time since the Spanish influenza of 1918, life expectancy is falling for a significant number of American women (washingtonpost.com) For the first time since the Spanish influenza of 1918, life expectancy is falling for a significant number of American women. Life expectancy is now shorter than it was in Although information is still coming out about Swine Flu, so far it doesn't seem to be as severe as Bird Flu or the flu that caused the Influenza Pandemic of 1918 (also known as Spanish Flu), but it is much too early to predict whether it will cause the next flu pandemic. From Wikipedia, the free encyclopedia New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. The Spanish flu pandemic in 1918/9, Asian flu in 1957, and Hong Kong flu in 1968 all killed millions. Wikipedia pages on passive immunity and monoclonal antibodies (note:Ned was sent to Great Yarmouth for basic training in 1918, It seemed the entire region was suffering from the Spanish influenza, and he was urged to stay on when nearly all of the nurses quit. Russell Coffey, 108, is another veteran who enlisted just weeks before the war ended and never got out According to Wikipedia, Influenza pandemic — An influenza pandemic is a large scale epidemic of the virus, such as the 1918 Spanish flu. The World Health Organization (WHO) warns that > read more Background from Wikipedia.org: H5N1 is a highly pathogenic strain of avian influenza, also known as bird flu. However this variant has mutated into the most lethal strain of influenza ever recorded. Such occurrences are natural and have happened in the past, as in the 1918 Spanish pandemic. Spanish Flu.

Courtesy: Yoshihiro Kawaoka, University of Wisconsin-Madison. Using genes resurrected from the 1918 Spanish virus, the virus responsible for a pandemic that killed an estimated 20 million people, scientists have gathered important new clues to why the virus spread quickly and killed efficiently.For several years now, health officials have been studying DNA extracted from frozen victims of the 1918 Spanish influenza pandemic buried in Alaska. Wikipedia blocks computers linked to Church of Scientology after repeated breaches Het eerste, milde scenario in de kolom "Mild Avian Influenza" is gebaseerd op de pandemieën van 1957 en 1968. Het tweede, strengere scenario in de kolom "Severe Avian Influenza" is ruwweg gebaseerd op de Spaanse grieppandemie van 1918-1919. Spanish Influenza (H1N1), 1918-1919 Zentrale Info Seite der WHO ; WHO: Avian influenza offizielle Seite der WHO zum Thema Vogelgrippe ; BBC Q&A: Avian flu; Vogelgrippe Q&A; BBC Mapping bird flu ; Aktueller Artikel in Science ( Anmeldung erforderlich ); The 1918 Influenza Pandemic; Spanish Flu - Wikipedia; Baden-Württemberg Landesärztekammer;A pandemic of the human virus has caused extensive morbidity and mortality around the world. The mechanisms involved in the emergence of new influenza The 1918 Spanish virus killed 25 million people worldwide, in 25 weeks[11],[12],[13] and hence a 6-8 months' period may prove too long a wait.; Wikipedia: Vitamin D All the doctors and people who were living at the time of the 1918 Spanish Influenza epidemic say it was the most terrible disease the world has ever had. Strong men, hale and hearty, one day would be dead the next. Wikipedia: vaccine In the world wide Spanish flu pandemic of 1918, "Physicians tried everything they knew, everything they had ever heard of, from the ancient art of bleeding patients, to administering oxygen, to developing new vaccines and sera (chiefly against what we now call Hemophilus influenzae—a 2009-Apr-28; Latest swine Flu Update Swine flu update and Info on Baxter flu vaccine As an example of an urgent need to add an agent, or even a form of information, came when the genetic coding of the variants to the influenza virus, which made the 1918 pandemic so deadly, were published.[5] Articles that originated in part from Wikipedia are available under GNU Free Documentation License 1.2.however more recent research suggests the 1918 pandemic was caused by the antigenic drift of a fully avian virus to a form that could infect humans efficiently. One increasingly worrying situation is the possible antigenic shift between avian influenza and human influenza.President Ford was acting on the advice of medical experts, who believed they were dealing with a virus potentially as deadly as the one that caused the 1918 Spanish pandemic. You could start with a search for Easter on Wikipedia.

But there is a much simpler and more important reason for this season.H1N1 1918-20: The Spanish Flu pandemic killed tens of millions of people worldwide (about twice as many as were killed in World War I). One in five suffered with this disease, and about one in 30 died. This pandemic may have killed more people than did the Black Plague. ↑ Vaccination for Influenza at Wikipedia The 1918 Pandemic; TheStar.com - Remembering the epidemic of 1918; The 1918 Influenza Pandemic; The American Experience | 1918; 1918 Spanish Flu pandemic; Spanish flu - Wikipedia ; Flu Wiki - Science - 1918 Pandemic; [Full text] An Avian Connection as a Catalyst to the 1918-1919 Influenza Pandemic;The greater Mexico City Metropolitan area has a population of 22 million people according to Wikipedia. Many millions of The two mechanisms by which pandemic originates. this from 2006 In 1918, the 'Spanish influenza' H1N1 virus, closely related to an avian virus, adapted to replicate efficiently in humans.2009-May-12; Posted in Just Thoughts We've already planted our Spanish onions, garlic, radishes, carrots, swish chard, green onions and endive.[Countries link to CIA Factbook. States link to Wikipedia.]; Hospitals "Full-Up": The 1918 Influenza Pandemic; A documentary comparing the 1918 Spanish Influenza pandemic with modern-day health capabilities, in the event of an act of bioterrorism or any large-scale infectious disease outbreak.The Wikipedia entry suggests that the virus may have mutated again to a less lethal strain some time in the winter. Across the United States about 28% came down with the flu and 500,000 to 675,000 died. Worldwide the disease may have killed as many as David Middlecamp on 1918 Spanish Influenza on the Central Coast III Spanish flu (influenza), 1918-1919, was a bird flu (a type of influenza). It spread through the world killing between 50 million and 100 million people[1].

This short article can be made longer. You can help Wikipedia by adding to it.legal issues health care workers refusing influenza vaccine wikipedia influenza, pandemic influenza update by idsa, and smoking influenza overnight, h5n1 'irradiation' bird flu avian influenza 1918 spanish influenza symptoms can you tell me what causes avian flu horse influenza cat - c.cura de la influenza pandemic influenza dvd. who developed the vaccination, avian bird flu influenza 1918 spanish influenza symptoms, usda avian influenza avian injury, equine jesus + influenza picture.Aethlon Medical, Inc. The study data was quantified by reverse transcription polymerase chain reaction (PCR). The Spanish Flu of 1918 is believed to have caused 40-50 million deaths during a two-year time span. The Hemopurifier® has also demonstrated effectiveness in capturing H5N1 avian influenza (bird flu).Using a gene resurrected from the virus that caused the 1918 Spanish influenza pandemic, recorded history's most lethal outbreak of infectious disease, scientists have found that a single gene may have been responsible for the devastating virulence of the virus. News Archive [link] Web Wikipedia Medical Dictionary [link]avian influenza florida health spanish influenza reed army hospital influenza 1918. influenza virus protein composition influenza vaccine consent form pandemic influenza dvd influenza genome - influenza / 1918 / milwaukee All and full information about Influenza and about effect it takes - wikipedia influenza,'graphs on influenza c', influenza vitamin d. influenza virus classification, influenza a nucleoprotein - california pandemic influenza summit 1918 spanish influenza symptoms - influenza in the 1940's. np protein and influenza, people with influenza, Delivery is fast and effect is stable hhs pandemic influenza plan.Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virus., , J, Taubenberger, Philos Trans R Soc Lond B Biol Sci, 2001 This article provided by Wikipedia.

To edit the contents of this article, click here for original source Note: For information about the content, tone and sourcing of this article, please see the tags at the bottom of this page.An influenza pandemic is an epidemic of the influenza virus that spreads on a worldwide scale and infects s large proportion of the human population. Spanish Flu 1918-20 40 million H1N1 From Wikipedia, the free encyclopedia The Pandemic of 1918 (or the Spanish Flu) killed 25-50 million people (about 2% of world population of 1.7 billion).[18] Today Influenza kills about 250,000 to 500,000 worldwide each year.For many thousands of years, humans have been manipulating plant and animal stocks—first by accident and later selectively—to meet changing societal and environmental needs. But the discovery of the structure of DNA in 1953, In 2001, scientists finished the initial draft of the human genome sequence,Bush needs a BATHroom break! ellroon | 09.21.05 - 5:26 pm | # Twenty Seventh. SWR | 09.21.05 - 5:26 pm | # Halllllooooooooo! Damn the acoustics in here are incredible when it's empty! bj | 09.21.05 - 5:27 pm | #Et søk i nyhetsagenten Mylder etter nyheter som inneholder ordet eller ordene panic Store Norske Wikipedia EN NO CDC says preliminary analysis hasnt shown any of the scientific markers associated with the virulence of the 1918 Spanish influenza virus. (16 dager gammel) Les saken >Characterization of the Reconstructed 1918 Spanish Pandemic Virus posted to influenza reconstruction spanish by kslibrarian on 2006-03-24 04:11:49 as along with 1 person friendpine Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus posted to influenza reconstruction spanish by kslibrarian on 2006-03-24 04:11:49 as along with 1 person friendpine Biometrics (Wikipedia) This event is the release of a hopped up version of 1918 Spanish ; Influenza. Don't believe for a moment that there's no vaccine. However you would have to be connected to the White House or very important to a top multinational to get it. 1918 March: 'Spanish' pandemic began in Fort Riley, Kansas; in the next year, as many as 100 million people "The Great Crash: 1929" [1954 classic] by John Kenneth Galbraith; Mariner Books 8&frac14x5½ pb [4/97] for $11.20; Houghton Mifflin mass pb [1/61] out of print/many used; book entry at Wikipedia In a timely press release from April 14th, Novavax and the CDC, released the results from a preclinical study showing that an investigational H1N1 virus-like particle (VLP) vaccine based on the 1918 Spanish influenza strain, protected against both the Spanish flu and a highly pathogenic H5N1 avian influenza strain.More similarities have been found between the bird flu creeping into Eastern Europe and the 1918 Spanish flu that decimated populations worldwide -- including the discovery of Dr. Allison McGeer, of Mount Sinai Hospital in Toronto, says more money and time needs to be spent on looking for new drugs for influenza,I have made a few minor changes to the references for the paperback edition (published, in the UK at least, on June 14 2007). These include updating web links, replacing "web-only" citations with rather more long-lived sources, and replacing all Wikipedia references with "traditional" (rather more rigorous) sources.1918 Spanish Influenza ; Famine ; 1282 Great Famine ; 1366 Great Famine ; 1431-1434 Famine ; 1679 Famine ; 1771 Great Famine ; 1845ff Potato Famine ; 1866 Famine caused by the War ; 1914-1918 Food Shortage in WW I ; Article Demographics of the Czech Republic, from Wikipedia ; Article Prague, from Jewish Virtual 1918 Spanish Influenza ; Famine ; 1431-1434 Famine ; 1845ff Potato Famine ; 1866 Famine caused by the War ; 1914-1918 Food Shortage in WW I ; 1939-1945 Food Shortage in WW II ; Labour Migration : Immigration ; Article Demographics of the Czech Republic, from Wikipedia ; Article Moravia,With the help of wikipedia and Radio Free Europe, I can confirm that it's a rough gig being a revolutionary.

Leaving aside Lenin & Stalin: Sverdlovv - died during the 1918 Spanish influenza epidemic.A solo exhibition of his work took place in Paris in 1914. In the autumn of 1918, the Spanish influenza epidemic that claimed more than 20,000,000 lives in Europe reached Vienna. Edith, who was six months pregnant, succumbed to the disease on 28 October.Know of place that is haunted? Let us know and we will add it to our listing. Shortly after her interment, Osa Wilson was an abused wife. Legend has it that her husband slapped her across the face, resulting in her falling down a flight of stairs, fatally injuring her and her unborn child. Her tombstone portrays a woman Comparisons to the 1918 Spanish influenza have produced death toll projections in excess of 360 million, evoking images of chaos in the streets. One does not qualify for funding -- whether for academic research, medical development or contingency studies -- by postulating about best-case scenarios.In contrast to the regular seasonal epidemics of influenza, these pandemics occur irregularly, with the 1918 Spanish flu the most serious pandemic in recent history. Pandemics can cause high levels of mortality, with the Spanish influenza being responsible for the deaths of over 50 million people.In contrast to the regular seasonal epidemics of influenza, these pandemics occur irregularly, with the 1918 Spanish flu the most serious pandemic in recent history. Pandemics can cause high levels of mortality, with the Spanish being responsible for the deaths of over 50 million people.If properly treated, the cat should be cured in a week or ten days, but if neglected influenza may open the way for serious viral disease. Even a simple cold is reason enough to keep a cat in a warm place, Influenza epidemics, such as the Spanish influenza of 1918, can result in massive devastation.The 1918 flu pandemic (commonly referred to as the Spanish flu) was an influenza pandemic that spread to nearly every part of the world.

It was caused by an unusually severe and deadly Influenza A virus strain of subtype H1N1. Historical and epidemiologic data are inadequate to identify the geographic Influenza, commonly known as the flu, is an infectious disease that affects birds and mammals caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses). The name influenza comes from the Italian: influenza, meaning "influence", (Latin: influentia).Hopefully the effect of the current H1N1 virus is not as catastrophic as the 1918 Spanish Influenza. Here is some information on the deadly 1918 flu outbreak (source - wikipedia).Wikipedia: Spanish Flu en.wikipedia.org Monessen and the Spanish Influenza of 1918 The Spanish Influenza 1918 9News in Colorado has an interview with a 100-year-old woman who survived the Spanish outbreak of 1918: * History of the 1918 Spanish Influenza Outbreak  * State-by-state statistics about the Spanish Outbreak of 1918 Spanish influenza in 1918? when or where did it happened. 3 weeks ago Source(s): http://en.wikipedia.org/wiki/1918_flu_pa 3 weeks ago. 0% 0 Votes Spanish flu research - Wikipedia, the free encyclopedia; Feb 7, 2009 Wikinews has related news: Scientists recreating the 1918 flu virus . " Characterization of the Reconstructed 1918 Spanish Influenza ;Characterization of the 1918 "Spanish" influenza virus neuraminidase gene on this page are information about the 1918, why The surface proteins of influenza viruses, hemagglutinin and neuraminidase, play important roles in virulence, host specificity, and the human immune response. The Spanish Flu From Wikipedia,Wikipedia encyclopedia Spanish influenza; Spanish epidemic; Spanish Inquisition; Spanish Inquisition; Spanish Inquisition; Spanish Inquisition (Monty Python); Spanish Inquisition sketch; Spanish Inquisiton; Spanish Inquisiton;The Spanish Flu reference article from the English Wikipedia on 24-Jul-2004; The Spanish Flu (also known as the Great Pandemic and La Grippe) was an unusually severe and deadly strain of influenza that killed some 25 million to 40 million people (possibly significantly more) world-wide in 1918 and 1919.An influenza pandemic is a large scale epidemic of the virus, such as the 1918 Spanish flu. 1918 Flu Resulted In Current Lineage Of H1N1 Swine Influenza Viruses (May 1, 2009) — In 1918 a human virus known as the Spanish flu spread through the central United States while a swine respiratory Wikipedia encyclopedia With only one exception--during the year 1918 when the worldwide Spanish epidemic made it advisable not to hold the fair--it has been an annual event.We all hear the horror stories of the Bubonic Plague in the 1300's, but less well known is the Spanish Flu Pandemic in 1918, which killed more people in one year than the Black Death killed in 4 years. Many people consider it to be the worst epidemic that Why did the 1918 Influenza Pandemic fade from American memory Influenza (Wikipedia); Spanish Flu (Wikipedia); The Influenza Pandemic of 1918; 1918 Influenza: the Mother of All Pandemics (Centers for Disease Control); Philadelphia, Nurses, and the Spanish Influenza Pandemic of 1918; Influenza in the United States, 1887-1956; Researchers Reconstruct 1918 Pandemic Influenza Other field research was that conducted on the devastating 1918 Spanish influenza virus remains, done primarily in 2005.

Spanish influenza killed approximately 50 million people and is believed to have jumped from birds directly to humans (Sample, 2005). This epidemic may have indirectly had much to do with ending the [FIXME: should I move this data to Wikipedia: List of wars and disasters by death toll ?] 8,000,000 . . . Est. civilians killed in Great War: Non-influenza 8,300,000 . . . . .

. . Estimated combatants killed, all nations 21,500,000 . . . . Min. deaths in 1918 Spanish Influenza PandemicAccording to Wikipedia, former MK Geula Cohen (who served in the Lehi) recounted having heard that a package bomb was addressed to 'R. Farran', and that they did not know at the time that he had a brother who shared his first initial. Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways—leading to improvements in public health, agriculture, and other areas. But the discovery of the structure of DNA in 1953, followed by the invention of DNA recombinant technology 1; Framing the Issue The American Experience: 1918 - Information on the film from the PBS series.

Features include, maps, timelines and people and events relating to this devastating occurrence. Wikipedia: Spanish Flu - Article about the 1918 Influenza pandemic with a look to geographical origins and social impact. Wikipedia: Spanish Flu - Article about the 1918 Influenza pandemic with a look to geographical origins and social impact. Is Another Influenza Pandemic Coming Soon? - Article from Infectious Disease News describing the investigation of a Spanish influenza sample found in WWI soldier's lungs.The outbreak of Spanish Influenza in 1918 to 1919 is believed to have been spread throughout the world by troops returning home after WWI. While it was only a short lived pandemic compared to others in history, estimates at the time put the global death toll between 40 and 50 Peoples Republic of China: Wikipedia The outbreak of Spanish Influenza in 1918 to 1919 is believed to have been spread throughout the world by troops returning home after WWI. While it was only a short lived pandemic compared to others in history, estimates at the time put the global death toll between 40 and 50 Peoples Republic of China: Wikipedia In the past century, there were three pandemics. The “Spanish influenza” of 1918 caused by the H1N1 subtype is estimated to have hit nearly a third of the world’s population (Figure 3A). Site Search Tags: Brevig+Mission, 1918, pandemic, Taubenberger, Spanish flu Poorest places in the United States - Wikipedia In February 1998, The Molecular Pathology Division of the US Armed Forces Institute of Pathology (AFIP) recovered samples of the 1918 influenza from the frozen corpse of a Native Alaskan woman buried for nearly eight decades in permafrost near Brevig Mission, Alaska. Spanish flu, Spanish flu - Mutation theory,There were three major influenza pandemics in the 20th Century. The 1918-19 "Spanish Influenza" was particularly deadly, killing anywhere between 30 and 50 million people around the world.

The 1957-58 Asian flu was not as deadly, but still killed about 70,000 Americans.The Spanish Influenza Epidemic of 1918 was caused by vaccinations---E. McBean (Swine Flu Expose) To see how many vaccines the soldiers could have received see the Wikipedia start dates:A pandemic of the human influenza virus has caused extensive morbidity and mortality around the world. The mechanisms involved in the emergence of new influenza viral strains and the epidemiological factors leading to pandemics The 1918 Spanish influenza virus killed 25 million people worldwide, in 25 weeks Childbirth Preparation and Baby Care Classes 5 classes per session - 4 Sessions per year; Read More Strength Training for Women; Personal Training Class - Individualized Training; Instructor: Gayla Oakley RN, Certified Personal Trainer; Schedule: Schedule to be announced for spring - Please Check Back He wrote "The Initial characterization of the 1918 Spanish Influenza Virues" which was published in Nature in March of 1997. This article has been cited 196 times.They helped care for massive numbers of sick and dying victims of the 1918 Spanish influenza outbreak. Apothecary, Wikipedia The great influenza epidemic of 1918-20 There was nothing "Spanish" about this flu. According to Wikipedia: "In the U.S., about 28% of So far the Bird Flu has only killed 160 people since 2003. Is it a harbinger of something more deadly? Hopefully it isn't but we should be mindful of the shocking precedent set by the 1918 Pandemic. -----Gripe Aviar H5N1 Información Mundial - Influenza Chile 1918 'Spanish Flu' Survivors May Hold Important Clues To Future Flu Fight; Research Into 1918 Virus Can Help Bird Flu Fight; Why Did The 'Spanish Flu' Kill So Quickly?; Wikipedia's 'Spanish Flu' Page Wikipedia entry on avian influenza Is the 1918 Influenza Pandemic Over? Long-Term Effects of in utero Influenza Exposure in the post-1940 U.S. Population. (author: Douglas Almond.

Columbia University and NBER, July 2005.) pdf The definitions are based primarily upon first-hand research and practical experience with OER projects, as well as on perusal of existing definitions offered by Wikipedia. For example, one user of a lesson plan about the Spanish influenza of 1918 might assign a tag such as flu, while another might assign a tag such In contrast to the regular seasonal epidemics of influenza, these pandemics occur irregularly, with the 1918 Spanish flu the most serious pandemic in recent history. Pandemics can cause high levels of mortality, with the Spanish influenza being responsible for the deaths of over 50 million people.There is an unresolved debate about the true origins of the Troubadours one can distinguish at least eleven competing theories according to Wikipedia. Some experts argue it had Arab roots originating in Spain, others say Celtic or Pictic origins and yet others see it's embryo in Classical Latin or feudal folk lore. 1918 Spanish Flu pandemic - An unusually severe and deadly strain of avian influenza, a viral infectious disease, that killed some 25 million to 50 million people worldwide in 1918 and 1919. It is thought to have been one of the most deadly pandemics in human history. Wikipedia - H5N1 A District council made up of 35 advisers - who elects a Junte (an executive) whose 13th president was named in July 2003 - vote regional laws. 1915 - 1918: First World War: 1557 valdôtains are killed either 2% of the total population. 1918 : The “Spanish Influenza” made: 1500 victims in the valley.1918 - Spanish Flu influenza (a deadly strain of bird flu) becomes a pandemic, and kills 25-50 million people within six months; *time passes*; 2004 - Red Sox win World Series; 2005 - White Sox win World Series, bird flu emerges; It's like Wikipedia, except super crackass. Take the Uncyclopedia article on emperor Peter Wilby on swine flu coverage: "Several papers, and particularly the Daily Mail, gave prominence to Professor Nigel Dimmock, a Warwick University virologist, who warned "this has the potential to be bigger than Spanish influenza", the 1918 pandemic that may have killed 50 million worldwide..